To explore the relationship between gut microbiome composition and the progression of subclinical atherosclerosis in people with HIV.
Key Findings:
Distinct microbial signatures associated with cIMT progression were identified, independent of traditional cardiovascular risk factors.
Increased levels of Agathobacter and Ruminococcus 2 were correlated with cIMT progression, while Prevotella 7 was associated with nonprogression.
Interpretation:
The observed changes in gut microbiome may reflect ecological adaptations to counteract inflammation rather than direct drivers of atherosclerosis, suggesting a complex interplay between gut health and cardiovascular risk in HIV.
Limitations:
Causal associations remain speculative due to the observational nature of the study.
Potential impact of unmeasured confounders such as dietary habits and environmental factors.
Conclusion:
The study highlights the gut microbiota's association with subclinical atherosclerosis progression in people with HIV, supporting further research into the microbiome's prognostic and therapeutic potential.
A small observational study in collegiate football players found microbiome associations after nonconcussive head impacts, though findings were limited by severe underpowering and high attrition
