Systemic Immune Responses in Patients with Spine Surgery Related Infections - Summary - MDSpire

Systemic Immune Responses in Patients with Spine Surgery Related Infections

  • By

  • Fehrenbach, Pia

  • Lang, Siegmund

  • Gocević, Maja

  • Kwant, Puk

  • Haschtmann, Daniel

  • Fekete, Tamas F.

  • Menzel, Ursula

  • De Jong, Esther Christina

  • Moriarty, Fintan Thomas

  • Grad, Sibylle

  • Loibl, Markus

  • May 4, 2026

  • 0 min

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Objective:

To examine changes in immune cell profiles in the blood of patients who developed infections after spinal surgery compared to control patients without infections.

Key Findings:
  • 30 immune cell clusters exhibited significant differences between Infection and Non-infection patients.
  • Natural killer cells and monocytes were decreased in Infection patients compared to Non-infection patients.
  • Th17, B cells, CD69+, and HLA-DR+ CD4+ T cells were significantly increased in Infection patients.
Interpretation:

Limitations:
  • The study sample size was relatively small (n=37).
  • Further research is needed to explore the clinical relevance of the identified immune markers.
Conclusion:

Original Source(s)

Systemic Immune Responses in Patients with Spine Surgery Related Infections

  • by Fehrenbach, Pia , Lang, Siegmund , Gocević, Maja , Kwant, Puk , Haschtmann, Daniel , Fekete, Tamas F., Menzel, Ursula , De Jong, Esther Christina, Moriarty, Fintan Thomas, Grad, Sibylle , Loibl, Markus

  • May 4, 2026

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