To examine the prevalence of familial cardiometabolic disease and its longitudinal association with specific cardiac structural (e.g., LV hypertrophy) and functional changes (e.g., diastolic function) from adolescence to young adulthood.
Key Findings:
30.2% of participants had a positive family history of cardiometabolic diseases.
Prevalence of LV hypertrophy increased from 2.4% at age 17 to 6.5% at age 24.
Youth with a positive family history showed a fourfold increase in LV hypertrophy prevalence compared to a two-fold increase in those without such history.
Positive family history significantly associated with worsening odds of LV hypertrophy (OR: 1.21) and high LV filling pressure (OR: 1.20, defined as E/eā² ā„8).
Interpretation:
Familial cardiometabolic history is linked to increased risk of cardiac structural changes in offspring, highlighting the importance of early identification and intervention to mitigate long-term health risks.
Limitations:
The study may not account for all potential confounding factors, such as lifestyle and environmental influences.
The sample size for certain analyses may limit generalizability to broader populations.
Conclusion:
Parental history of cardiometabolic diseases significantly impacts cardiac health in offspring, emphasizing the need for early monitoring and preventive strategies.
