Objective:

To analyze the epidemiology of patent ductus arteriosus (PDA) and outcomes of transcatheter closure in neonates in Qatar.

Approach:

• Study Design: Retrospective analysis of 80 infants diagnosed with PDA at Sidra Medicine, Qatar, from 2018 to 2024.
• Data Collection: Data obtained from electronic health records, including demographics, PDA characteristics, and treatment outcomes.
• Statistical Analysis: Statistical analysis performed using SPSS version 29, with significance set at p ≤ 0.05.

Key Findings:

• 60% of patients were male and 83.75% were born prematurely.
• Transcatheter device closure was performed in 65% of patients.
• Gestational age <37 weeks significantly associated with catheter-based treatment (p ≤ 0.05).
• PDA murmur increased likelihood of catheter-based intervention eightfold (OR 8.125; p < 0.001).
• Implant success rate was 86.5% on the first attempt and 100% after repeat intervention.
• Intraprocedural complications included device embolization in 4 patients.
• Residual shunt resolved in all patients with follow-up data at six months.

Interpretation:

PDA closure via transcatheter approach shows high success rates and acceptable safety in preterm infants, with gestational age, birth weight, and ductal size being key factors influencing outcomes.

Limitations:

• Study excluded patients requiring surgical intervention, which may limit generalizability based on the study design.
• Retrospective design may introduce selection bias related to patient selection.

Conclusion:

Transcatheter closure of PDA is feasible in preterm infants, emphasizing the importance of patient selection.