Serial extracellular volume quantification using cardiac magnetic resonance imaging in transthyretin amyloidosis patients treated with tafamidis - Summary - MDSpire

Serial extracellular volume quantification using cardiac magnetic resonance imaging in transthyretin amyloidosis patients treated with tafamidis

  • By

  • Franz Duca

  • Michael Poledniczek

  • Christina Kronberger

  • Christina Binder

  • René Rettl

  • Luciana Camuz-Ligios

  • Hermine Agis

  • Matthias Koschutnik

  • Carolina Donà

  • Roza Badr-Eslam

  • Dietrich Beitzke

  • Christian Loewe

  • Christian Nitsche

  • Christian Hengstenberg

  • Johannes Kastner

  • Jutta Bergler-Klein

  • Andreas Anselm Kammerlander

  • July 16, 2025

  • 0 min

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Objective:

To investigate the prognostic relevance of serial extracellular volume (ECV) quantification in ATTR CA patients treated with tafamidis, highlighting its potential impact on patient outcomes.

Key Findings:
  • Patients treated with tafamidis showed stabilization of ECV (47.5% vs 47.7%) compared to treatment-naïve patients (49.3% vs 54.6%), indicating potential treatment efficacy.
  • Reduction in SUV retention index from 5.96 g/mL to 3.27 g/mL in tafamidis-treated patients, suggesting improved amyloid burden.
Interpretation:

Decreasing amyloid burden in tafamidis-treated ATTR CA patients, as assessed by serial CMR T1-mapping, may correlate with better clinical outcomes, warranting further investigation.

Limitations:
  • Retrospective design may introduce bias, and small sample size limits generalizability; potential confounding factors should be acknowledged.
Conclusion:

Serial ECV quantification using CMR may help identify ATTR CA patients who benefit most from tafamidis treatment, warranting further dedicated studies to validate these findings.

Original Source(s)

Serial extracellular volume quantification using cardiac magnetic resonance imaging in transthyretin amyloidosis patients treated with tafamidis

  • by Franz Duca, Michael Poledniczek, Christina Kronberger, Christina Binder, René Rettl, Luciana Camuz-Ligios, Hermine Agis, Matthias Koschutnik, Carolina Donà, Roza Badr-Eslam, Dietrich Beitzke, Christian Loewe, Christian Nitsche, Christian Hengstenberg, Johannes Kastner, Jutta Bergler-Klein, Andreas Anselm Kammerlander

  • July 16, 2025

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