To assess the correlation of gene polymorphisms in CYP2R1, CYP24A1, CYP27B1, and DBP with susceptibility to breast cancer in Jordanian women, highlighting the role of vitamin D in cancer risk.
Key Findings:
CYP2R1 rs12794714 and CYP27B1 rs10877012 showed significant associations with breast cancer risk, with the GG genotype of CYP2R1 and the TG genotype of CYP27B1 associated with a reduced risk of breast cancer.
No significant associations were found for CYP2R1 rs10741657, CYP24A1 rs2248359, or DBP rs7041 and rs4588 variants.
Interpretation:
Certain genotypes in CYP2R1 and CYP27B1 may provide protective influences against breast cancer in Jordanian females, suggesting potential avenues for genetic screening.
Limitations:
The study is limited to a specific population, which may affect the generalizability of the findings, and potential biases in case-control design should be considered.
Further studies are recommended to validate the results and explore the mechanisms behind the associations.
Conclusion:
The study suggests a potential link between specific genetic variants and breast cancer risk, warranting further investigation to confirm these findings and their implications for prevention strategies.
by Laith N. Al-Eitan, Maryam K. Alasmar, Mohammed S. Alorjani, Lina M. Sarhan, Sakher S. Sammour, Farah N. Aladwan, Hadil A. Al Refai, Sara S. Hasanat, Mira S. Quran, Mansour A. Alghamdi
