Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes - Summary - MDSpire

Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes

  • By

  • Yi-Ting Lin

  • Sergi Sayols-Baixeras

  • Tiscar Graells

  • Koen F Dekkers

  • Gabriel Baldanzi

  • Diem Nguyen

  • Anders Larsson

  • Tobias Rudholm Feldreich

  • Nynne Nielsen

  • Aron C Eklund

  • Jacob B Holm

  • H Bjørn Nielsen

  • Göran Bergström

  • J Gustav Smith

  • Andrei Malinovschi

  • Gunnar Engström

  • Marju Orho-Melander

  • Tove Fall

  • Johan Ärnlöv

  • August 14, 2025

  • 0 min

Share

Objective:

To investigate the relationship between gut microbiome composition, plasma metabolites, and albuminuria in individuals with type 2 diabetes, emphasizing the significance of albuminuria in diabetes management.

Key Findings:
  • Three gut microbial species (Sellimonas intestinalis, Eggerthellales sp., Ellagibacter isourolithinifaciens) were associated with albuminuria, contributing to the understanding of the gut-kidney axis.
  • 36 annotated metabolites were linked to the three albuminuria-signature species.
  • Functional mapping suggested a role of these species in regulating metabolites like imidazole propionate and trigonelline, which are implicated in albuminuria progression.
Interpretation:

The study provides evidence that specific gut microbiome profiles and their metabolites may influence the development of albuminuria in type 2 diabetes, highlighting the gut-kidney axis and potential clinical implications.

Limitations:
  • The study is observational and cannot establish causation, which may introduce biases.
  • The sample size for the replication analysis was limited to prediabetic individuals.
Conclusion:

The findings enhance understanding of the relationship between gut microbiome, metabolites, and albuminuria, suggesting potential targets for therapeutic intervention in type 2 diabetes management and the need for further research to validate these findings.

Original Source(s)

Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes

  • by Yi-Ting Lin, Sergi Sayols-Baixeras, Tiscar Graells, Koen F Dekkers, Gabriel Baldanzi, Diem Nguyen, Anders Larsson, Tobias Rudholm Feldreich, Nynne Nielsen, Aron C Eklund, Jacob B Holm, H Bjørn Nielsen, Göran Bergström, J Gustav Smith, Andrei Malinovschi, Gunnar Engström, Marju Orho-Melander, Tove Fall, Johan Ärnlöv

  • August 14, 2025

Related Content

Diabetic Retinal Disease Rates Narrow by Diabetes Type

US claims data showed rising prevalence of diabetic retinal disease in type 1 and type 2 diabetes, while incidence declined in type 1 diabetes and moved closer to type 2 rates by 2022.

AI Scribes Lag Clinicians on Note Quality

A VHA study across 11 vendors finds AI-generated primary care notes score lower than clinician-written notes, with the largest deficits in thoroughness, organization, and usefulness

AACE 2026: Will AI replace endocrinologists?

The same technology drawing patients away from clinic may also improve the patient-physician relationship.