Mucocutaneous Disease Activity and Damage Accrual in Systemic Lupus Erythematosus: Analyses From the Asia-Pacific Lupus Collaboration Longitudinal Cohort Study - Summary - MDSpire
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Assessment of Mucocutaneous Disease Activity and Accumulation of Damage in Systemic Lupus Erythematosus: Insights from the Asia-Pacific Lupus Collaboration Longitudinal Cohort Study

  • By

  • Amanda M. Saracino

  • Yanjie Hao

  • Dylan Hansen

  • Yi-Hsing Chen

  • Alberta Hoi

  • Vera Golder

  • Jiacai Cho

  • Aisha Lateef

  • Worawit Louthrenoo

  • Laniyati Hamijoyo

  • Shue Fen Luo

  • Yeong-Jian Jan Wu

  • Sandra Navarra

  • Leonid Zamora

  • Chak Sing Lau

  • Shirley Chan

  • Zhanguo Li

  • Hai-hong Yao

  • Sargunan Sockalingam

  • B. M. D. B. Basnayake

  • Yasuhiro Katsumata

  • Masayoshi Harigai

  • Zhuoli Zhang

  • Jun Kikuchi

  • Yuko Kaneko

  • Tsutomu Takeuchi

  • Madelynn Chan

  • Sang-Cheol Bae

  • Fiona Goldblatt

  • Sean O'Neill

  • Geraldine Hassett

  • Kristine Ng

  • Nicola Tugnet

  • Mark Sapsford

  • Yih Jia Poh

  • Michael Tee

  • Cherica Tee

  • Naoaki Ohkubo

  • Yoshiya Tanaka

  • Rangi Kandane-Rathnayake

  • Eric Morand

  • Shereen Oon

  • Mandana Nikpour

  • May 10, 2026

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Objective:

To describe the prevalence and health-related quality of life (HRQoL) impact of mucocutaneous disease activity (MC-A) and damage (MC-D) in a large multinational prospective longitudinal cohort and to identify correlates of MC-A and potential predictors of subsequent MC-D.

Approach:
  • Research Setting: Utilized precollected data from the Asia-Pacific Lupus Collaboration (APLC) longitudinal cohort study, the largest international cohort of SLE patients.
  • Patients: Included consecutive patients with at least two visits and two SLICC/ACR Damage Index assessments from January 2013 to March 2021.
  • Definitions: Defined disease activity using SLEDAI-2K and disease damage using SDI, with specific criteria for MC-A and MC-D.
  • Statistical Methodology: Employed descriptive statistics, generalized estimating equations (GEE), and survival analyses to explore relationships and predictors.
Key Findings:
  • Mucocutaneous activity is prevalent in 70% to 85% of SLE patients and often the first clinical manifestation in 25%.
  • Persistent mucocutaneous activity is linked to a higher risk of damage accrual.
  • Mucocutaneous manifestations significantly impact health-related quality of life.
Interpretation:

Limitations:
  • The study relies on data from a specific cohort, which may limit generalizability.
  • Potential biases in self-reported HRQoL measures.
Conclusion:

Mucocutaneous disease activity in SLE is common and associated with significant quality of life impacts, necessitating early intervention.

Original Source(s)

Mucocutaneous Disease Activity and Damage Accrual in Systemic Lupus Erythematosus: Analyses From the Asia-Pacific Lupus Collaboration Longitudinal Cohort Study

  • by Amanda M. Saracino, Yanjie Hao, Dylan Hansen, Yi-Hsing Chen, Alberta Hoi, Vera Golder, Jiacai Cho, Aisha Lateef, Worawit Louthrenoo, Laniyati Hamijoyo, Shue Fen Luo, Yeong-Jian Jan Wu, Sandra Navarra, Leonid Zamora, Chak Sing Lau, Shirley Chan, Zhanguo Li, Hai-hong Yao, Sargunan Sockalingam, B. M. D. B. Basnayake, Yasuhiro Katsumata, Masayoshi Harigai, Zhuoli Zhang, Jun Kikuchi, Yuko Kaneko, Tsutomu Takeuchi, Madelynn Chan, Sang-Cheol Bae, Fiona Goldblatt, Sean O'Neill, Geraldine Hassett, Kristine Ng, Nicola Tugnet, Mark Sapsford, Yih Jia Poh, Michael Tee, Cherica Tee, Naoaki Ohkubo, Yoshiya Tanaka, Rangi Kandane-Rathnayake, Eric Morand, Shereen Oon, Mandana Nikpour

  • May 10, 2026

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