To systematically review the regulatory network and metabolic correlation mechanisms of lactylation modification and its clinical significance in gynecological diseases, emphasizing the systematic nature of the review.
Key Findings:
Lysine lactylation (Kla) is a novel post-translational modification linked to gene transcription and cellular metabolism, with specific examples of its impact on various gynecological disorders.
Interpretation:
Lactylation represents a critical intersection of metabolism and epigenetics, with significant implications for the understanding and treatment of gynecological diseases, highlighting areas for future research.
Limitations:
A systematic review summarizing the mechanistic role of lactylation in gynecological diseases is currently lacking, particularly in understanding its therapeutic potential.
Conclusion:
This review provides a foundation for future research and clinical applications in precision diagnosis and treatment of gynecological diseases related to lactylation, emphasizing its clinical importance.
A two-marker methylated DNA assay identified endometrial cancer with 96% sensitivity in self-collected vaginal fluid — but prospective validation is needed before it can reduce biopsies in routine care.
