To systematically review the regulatory network and metabolic correlation mechanisms of lactylation modification and its clinical significance in gynecological diseases, emphasizing the systematic nature of the review.
Approach:
Key Findings:
Lysine lactylation (Kla) is a novel post-translational modification linked to gene transcription and cellular metabolism, with specific examples of its impact on various gynecological disorders.
Interpretation:
Lactylation represents a critical intersection of metabolism and epigenetics, with significant implications for the understanding and treatment of gynecological diseases, highlighting areas for future research.
Limitations:
A systematic review summarizing the mechanistic role of lactylation in gynecological diseases is currently lacking, particularly in understanding its therapeutic potential.
Conclusion:
This review provides a foundation for future research and clinical applications in precision diagnosis and treatment of gynecological diseases related to lactylation, emphasizing its clinical importance.
A large BRFSS analysis points to persistent screening disparities among sexual orientation and gender identity minority respondents, with particularly large gaps in some gender identity minority groups.
