Clinical Features and Prognostic Outcomes in Patients with Ocular Syphilis and HIV Co-Infection - Summary - MDSpire
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Clinical Features and Prognostic Outcomes in Patients with Ocular Syphilis and HIV Co-Infection

  • By

  • Wenjun Kong

  • Fang Ruan

  • Lianyong Xie

  • Xia Feng

  • Yanqing Gao

  • Zhuyun Qian

  • Yong Tao

  • November 19, 2025

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Objective:

To evaluate the subtype of ocular manifestations, including uveitis and optic neuritis, and visual prognosis in patients with co-infection of ocular syphilis and HIV.

Approach:
    Key Findings:
    • Mean baseline LogMAR BCVA improved significantly from 1.08 to 0.86 after treatment (p < 0.001).
    Interpretation:

    The study highlights the complexity of diagnosing and treating ocular syphilis in HIV co-infected patients, emphasizing the need for tailored management strategies.

    Limitations:
    • Small sample size of 31 patients may limit generalizability and introduce biases due to being conducted in a single center.
    Conclusion:

    Ocular syphilis in HIV co-infected patients presents significant visual impairment, but timely treatment can lead to improved visual outcomes.

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