Objective:

To investigate the regulatory role of intestinal deoxycholic acid (DCA) in high-fat diet (HFD)-induced anxiety- and depression-like behaviors and to explore the underlying mechanisms.

Approach:

Key Findings:

• DCA intervention induced HFD-like anxiety- and depression-like behaviors in mice.
• Reduced levels of Clostridium_sensu_stricto_1 and its metabolite indole-3-propionic acid (IPA) were observed.
• IPA supplementation restored circulating IPA levels, ameliorated DCA-induced emotional and behavioral abnormalities, and upregulated key genes involved in the gut-brain axis.
• FMT induced similar behavioral phenotypes and gut-brain axis impairments as observed in DCA model mice.

Interpretation:

The findings suggest a gut-brain pathway linking HFD-associated DCA elevation to anxiety- and depression-like behaviors in mice, with reduced IPA levels identified as a key mediating factor influencing these behaviors.

Limitations:

• The study does not address potential long-term effects of DCA or IPA supplementation on behavior.

Conclusion:

Targeting abnormal bile acid metabolism or restoring IPA function may be a promising intervention strategy for HFD-related emotional and behavioral abnormalities.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.