OAGB 2025. A systematic review with meta-analysis of indications and results for primary procedures at 5+ years - Summary - MDSpire

OAGB 2025. A systematic review with meta-analysis of indications and results for primary procedures at 5+ years

  • By

  • Mario Musella

  • Sonja Chiappetta

  • Antonio Franzese

  • Pasquale Avella

  • Vincenzo Schiavone

  • Alessandra D’Ambrosio

  • Lucrezia Borrelli

  • Gerardo D’Amato

  • October 2, 2025

  • 0 min

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Objective:

To analyze the current status regarding indications and long-term results of One-Anastomosis Gastric Bypass (OAGB), emphasizing its significance in bariatric surgery.

Key Findings:
  • OAGB is effective for long-term weight loss and metabolic improvement, with a significant reduction in HbA1c and higher remission rates for type 2 diabetes compared to RYGB and SG, particularly in terms of BMI reduction.
  • Long-term complications include bile reflux, malnutrition, vitamin deficiencies, and marginal ulcers, which should be closely monitored.
  • Some studies report higher rates of GERD and conversion to RYGB, while others indicate a low rate of revisional surgery after OAGB, suggesting variability in outcomes.
Interpretation:

OAGB is a recognized and effective bariatric procedure with notable benefits for weight loss and metabolic health, though it carries risks of specific long-term complications that require careful management.

Limitations:
  • The review only included studies published in English, potentially limiting the scope of findings and introducing bias.
  • Exclusion of studies with less than 60 months follow-up may omit relevant short-term data that could inform patient selection.
Conclusion:

OAGB is a viable option for severe obesity treatment, demonstrating effective long-term outcomes, but careful patient selection and ongoing monitoring for complications are essential.

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