The Role of Neutrophil-to-Lymphocyte Ratio in Severe Neonatal SARS-CoV-2 Infections: Links to Changes in Lymphocyte Subpopulations - Summary - MDSpire

The Role of Neutrophil-to-Lymphocyte Ratio in Severe Neonatal SARS-CoV-2 Infections: Links to Changes in Lymphocyte Subpopulations

  • By

  • Guangliang Bi

  • Qingyan Xiao

  • Jie He

  • Shuzhe Xiao

  • Jie Yang

  • February 26, 2026

  • 0 min

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Objective:

To analyze the association between neutrophil-to-lymphocyte ratio (NLR) and disease severity in SARS-CoV-2-positive term neonates, highlighting its potential significance in neonatal health.

Key Findings:
  • Elevated NLR levels were associated with increased severity of COVID-19 in neonates, with specific statistical significance values.
  • Neonates exhibited atypical cytokine profiles, including elevated IL-6 and IL-10.
  • Significant differences in lymphocyte subpopulations were observed in severe cases compared to controls.
Interpretation:

The findings suggest that NLR may serve as a prognostic marker for severe COVID-19 in neonates, reflecting underlying immune dysregulation and its implications for clinical practice.

Limitations:
  • Retrospective design may introduce selection bias.
  • Limited sample size may affect generalizability.
  • Data collection relied on electronic medical records, which may have inconsistencies, and potential biases in data collection methods.
Conclusion:

NLR appears to be a valuable indicator of disease severity in neonates with SARS-CoV-2 infections, warranting further investigation into its clinical utility and specific areas for future research.

Original Source(s)

The Role of Neutrophil-to-Lymphocyte Ratio in Severe Neonatal SARS-CoV-2 Infections: Links to Changes in Lymphocyte Subpopulations

  • by Guangliang Bi, Qingyan Xiao, Jie He, Shuzhe Xiao, Jie Yang

  • February 26, 2026

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