Add-on benefits of botulinum toxin type A in combination or sequential therapies for scar management: a systematic review and meta-analysis - Summary - MDSpire

Add-on benefits of botulinum toxin type A in combination or sequential therapies for scar management: a systematic review and meta-analysis

  • By

  • Yunfei Ma

  • Wanming Qu

  • June 11, 2026

  • 0 min

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Objective:

To evaluate the efficacy of BoNT-A as an adjunctive component of combination or sequential therapies for scar management.

Approach:
    Key Findings:
    • Six randomized controlled trials (RCTs) were included in the analysis.
    • BoNT-A add-on therapy significantly improved scar appearance with a Mean Difference (MD) of -1.80 for the VSS score and 1.46 for the SBSES score.
    Interpretation:

    Current low-certainty evidence suggests that BoNT-A may provide a potential adjunctive benefit for improving scar appearance, particularly in mitigating local mechanical tension.

    Limitations:
    • Pooled estimates reflect heterogeneous treatment paradigms.
    • Most trials involved small sample sizes and variable follow-up durations.
    Conclusion:

    Findings are suggestive rather than confirmatory and strictly exploratory, with clinical application needing to be cautious and individualized.

    Sources:

Original Source(s)

Add-on benefits of botulinum toxin type A in combination or sequential therapies for scar management: a systematic review and meta-analysis

  • by Yunfei Ma, Wanming Qu

  • June 11, 2026

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