To report a case of successful treatment of residual extramammary Paget's disease (EMPD) using intralesional aminolevulinic acid photodynamic therapy (ALA-PDT).
Approach:
Patient Background: An elderly male with scrotal EMPD underwent surgical excision, which revealed positive margins and tumor infiltration into subcutaneous fat.
Treatment Method: Intralesional 5-aminolevulinic acid (ALA) was injected monthly into the residual plaque, followed by light irradiation.
Monitoring and Results: The treatment involved three sessions, leading to marked thinning and fading of the plaque, with complete regression after six sessions.
Key Findings:
Intralesional ALA-PDT achieved complete clinical regression of residual EMPD.
The treatment was well-tolerated with mild pain and transient erythema.
No recurrence was observed during the 6-month follow-up period.
Interpretation:
Intralesional ALA-PDT is effective for treating EMPD with deep dermal invasion.
Limitations:
The study is based on a single case report, limiting generalizability.
Long-term efficacy and safety beyond 6 months remain to be established.
Conclusion:
Intralesional ALA-PDT represents a minimally invasive option for residual EMPD.
