Culture-negative cryptogenic splenic abscess in an immunocompetent host with recurrent misdiagnosis as pleural effusion: a case report with a review of the literature - Summary - MDSpire

Culture-negative cryptogenic splenic abscess in an immunocompetent host with recurrent misdiagnosis as pleural effusion: a case report with a review of the literature

  • By

  • Andrio Palayukan

  • Ummi Maimunah

  • June 26, 2026

  • 0 min

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Objective:

To report a case of cryptogenic, culture-negative splenic abscess in an immunocompetent male and illustrate the diagnostic challenges.

Approach:
  • Case Description: A 52-year-old immunocompetent male presented with fever and abdominal pain after being misdiagnosed with pneumonia and pleural effusion. Diagnostic imaging and laboratory tests led to the identification of a splenic abscess.
Key Findings:
  • The patient had a culture-negative splenic abscess, initially misdiagnosed as pleural effusion.
  • Computed tomography confirmed multiple hypodense splenic lesions.
  • Surgical intervention was necessary due to the failure of antibiotic therapy.
Interpretation:

Culture negativity in splenic abscess cases should prompt consideration for surgical intervention rather than delay.

Limitations:
  • The case highlights the diagnostic challenges in identifying splenic abscesses, particularly in immunocompetent patients without clear predisposing factors.
Conclusion:

This case highlights the importance of timely diagnosis and intervention in culture-negative splenic abscess.

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