A Pilot, Single-Arm Feasibility Study of a Multidimensional Behavioural Intervention for Cognitive Fatigability in Multiple Sclerosis: Mental Energy Boost Program - Summary - MDSpire

A Pilot, Single-Arm Feasibility Study of a Multidimensional Behavioural Intervention for Cognitive Fatigability in Multiple Sclerosis: Mental Energy Boost Program

  • By

  • Islam, Tamanna

  • Berard, Jason

  • Ryan, Abby

  • Finlayson, Marcia

  • Pilutti, Lara

  • Morrow, Sarah

  • Walker, Lisa Ann Smith

  • April 29, 2026

  • 0 min

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Objective:

To assess the feasibility of an 8-week, group-based, videoconference-delivered behavioral intervention for cognitive fatigability (CF) in people with multiple sclerosis (PwMS).

Key Findings:
  • 54% of screened PwMS were eligible, with 86% enrollment reflecting high recruitment uptake.
  • 92% of participants rated their satisfaction >5 on a 10-point scale.
  • Per session attendance averaged 81.62%, with an 89% completion rate.
  • High treatment fidelity was observed, with 79% adherence to session length.
Interpretation:

Most feasibility indicators met 'GREEN' criteria, suggesting readiness to proceed to a full-scale randomized controlled trial (RCT), with the recruitment period needing adjustments.

Limitations:
  • Recruitment period duration fell within the AMBER zone, indicating procedural adjustments are necessary.
Conclusion:

The study supports progression to a full trial, with no indicators falling in the RED zone.

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