Outcome of Patients with Single Ventricles who Initially did not Indicate Fontan Completion After Stage II Palliation - Summary - MDSpire
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Clinical Outcomes in Single Ventricle Patients Who Initially Did Not Pursue Fontan Completion Following Stage II Palliation

  • By

  • Carolin Niedermaier

  • Cornelius Przybilla

  • Thibault Schaeffer

  • Muneaki Matsubara

  • Christina Ruda

  • Jonas Palm

  • Nicole Piber

  • Peter Ewert

  • Jürgen Hörer

  • Masamichi Ono

  • July 13, 2026

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Objective:

To evaluate the initial causes of contraindication for Fontan completion, the clinical course during follow-up, and outcomes after delayed Fontan completion in patients who initially did not undergo the procedure.

Approach:
  • Study Design: Retrospective single-center study reviewing infants with univentricular hearts who underwent BCPS between 1998 and 2022.
  • Data Collection: Clinical data were collected from hospital and outpatient records, including demographics, cardiac anatomy, perioperative details, and clinical status.
  • Assessment Criteria: Cardiac catheterization assessed pulmonary artery pressure, ventricular function, and significant atrioventricular valve regurgitation.
Key Findings:
  • A significant proportion of patients could not undergo Fontan completion due to elevated pulmonary artery pressure, reduced ventricular function, or significant atrioventricular valve regurgitation.
  • Some patients were able to achieve Fontan circulation after re-assessment and appropriate medical or interventional therapies.
Interpretation:

Limitations:
  • The study is retrospective and conducted at a single center, which may limit generalizability.
  • Data availability was restricted, and individual patient consent was waived.
Conclusion:

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