To comprehensively assess C-reactive protein (CRP) expression patterns, cellular origins, and disease-specific roles across various autoimmune conditions, emphasizing its clinical significance.
Key Findings:
CRP levels show considerable heterogeneity across autoimmune conditions, including systemic lupus erythematosus and rheumatoid arthritis.
CRP identified as a core inflammatory mediator in rheumatoid arthritis.
Positive correlations between CRP levels and systemic inflammatory burden.
Liver-derived single-cell data provide insights into inflammatory landscapes in autoimmune hepatitis.
Interpretation:
CRP interpretation in autoimmune diseases requires consideration of disease type and clinical context for effective early detection and patient stratification, highlighting its role in clinical decision-making.
Limitations:
Study primarily based on retrospective data, which may introduce bias.
Heterogeneity in patient populations may affect generalizability.
Potential confounding factors not fully explored, including treatment variations.
Conclusion:
The study maps CRP expression across autoimmune diseases, highlighting the need for context-specific interpretation to improve clinical management and patient outcomes.
Survey data show gaps between rheumatologists’ beliefs and clinical practice in screening and neuropsychological evaluation for childhood-onset systemic lupus erythematosus
