Clinical characteristics and predictors of prolonged hospitalization in patients with cosmetic botulinum toxin poisoning: a retrospective cohort study - Summary - MDSpire

Clinical characteristics and predictors of prolonged hospitalization in patients with cosmetic botulinum toxin poisoning: a retrospective cohort study

  • By

  • Yu-quan Chen

  • Yi-fan Ye

  • Mei-wen Xie

  • Yu-qiang Lin

  • Zhi-qian Yang

  • Zhi Wang

  • June 22, 2026

  • 0 min

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Objective:

To describe the clinical characteristics of cosmetic botulinum toxin poisoning and identify factors associated with longer hospital stays.

Approach:
    Key Findings:
    • 145 patients included, median age 37 years, 97.93% female.
    • Common injection sites: forehead (26.35%), periocular region (16.77%), jaw (11.98%).
    • Frequent manifestations: dizziness (89.66%), dysphagia (85.52%), blurred vision (75.17%), ptosis (68.28%), slurred speech (24.83%).
    • Dysphagia, slurred speech, and duration of antitoxin therapy were independently associated with prolonged hospitalization.
    Interpretation:

    Cosmetic botulinum toxin poisoning is characterized mainly by cranial nerve-related and bulbar manifestations. The nomogram developed may assist in early risk stratification and inpatient management.

    Limitations:
    • Retrospective design may introduce bias.
    • Lack of laboratory confirmation for botulinum toxin.
    Conclusion:

    Dysphagia, slurred speech, and antitoxin treatment duration are significant predictors of prolonged hospitalization.

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