MRI-derived IVIM-modelled diffusion-weighted imaging does not predict clinical outcomes in fontan-associated liver disease: to monitor or not to monitor the liver? - Summary - MDSpire

MRI-derived IVIM-modelled diffusion-weighted imaging does not predict clinical outcomes in fontan-associated liver disease: to monitor or not to monitor the liver?

  • By

  • Gaston van Hassel

  • Frans J. C. Cuperus

  • Paul E. Sijens

  • Tineke P. Willems

  • Eryn T. Liem

  • Elke S. Hoendermis

  • Joost P. van Melle

  • Rolf M. F. Berger

  • June 22, 2026

  • 0 min

Share

Objective:

To investigate the prognostic value of MRI-derived IVIM-modelled DWI in patients with a Fontan circulation.

Approach:
    Key Findings:
    • Meancohortagewas19±8years,with51%female.MeanADCwas(0.82±0.11)×10−3mm2/s,Dfast(20.74±6.60)×10−3mm2/s,ffast29±05%,andDslow(0.77±0.15)×10−3mm2/s.Theprimaryendpointoccurredin33patients(59%)duringamedianfollow-uptimeof9years.
    Interpretation:

    IVIM-modelled DWI can distinguish between hepatic congestion and fibrosis in FALD.

    Limitations:
    • The study was conducted at a single center, which may limit generalizability.
    • The sample size of 59 patients may not provide sufficient power to detect subtle associations.
    Conclusion:

    IVIM-modelled DWI does not predict clinical outcomes in FALD.

Original Source(s)

MRI-derived IVIM-modelled diffusion-weighted imaging does not predict clinical outcomes in fontan-associated liver disease: to monitor or not to monitor the liver?

  • by Gaston van Hassel, Frans J. C. Cuperus, Paul E. Sijens, Tineke P. Willems, Eryn T. Liem, Elke S. Hoendermis, Joost P. van Melle, Rolf M. F. Berger

  • June 22, 2026

Related Content

Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis

Spatial single-cell omics: new insights into liver diseases

Expanding Access to Liver Transplant: Why Barnes-Jewish Hospital and WashU Medicine Launched an Adult Living Donor Program

For hepatologists and other physicians who treat patients with advanced liver disease, the gap between the number of patients who need transplant and the number of available organs is a familiar challenge.

  • by

  • June 17, 2026

  • 5 min