Transition to tenecteplase is associated with shorter door-to-puncture times: a retrospective study from the Lone Star Stroke consortium TNK registry - Summary - MDSpire

Transition to tenecteplase is associated with shorter door-to-puncture times: a retrospective study from the Lone Star Stroke consortium TNK registry

  • By

  • Anqi Luo

  • Sujani Bandela

  • Gretchel Gealogo-Brown

  • Mark P. Goldberg

  • Andrew Slusher

  • Reza Behrouz

  • Alibay Jafarli

  • Siddarth Prasad

  • DaiWai Olson

  • Maria Denbow

  • Mehari Gebreyohanns

  • Asmiet Techan

  • Chethan P. Venkatasubba Rao

  • Jane A. Anderson

  • Barbara Kimmel

  • Anette Ovalle

  • Michele Patterson

  • Sean I. Savitz

  • Salvador Cruz-Flores

  • Steven Warach

  • Lee Birnbaum

  • May 4, 2026

  • 0 min

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Objective:

To compare door-to-puncture (DTP) times and discharge outcomes in patients treated with Tenecteplase (TNK) versus Alteplase (ALT) before thrombectomy.

Key Findings:
  • TNK group had significantly shorter DTP times (80 min) compared to ALT group (101.5 min), P < 0.001.
  • Needle-to-puncture times were shorter with TNK (39 min) compared to ALT (55 min), P < 0.001.
  • No significant differences in door-to-imaging and imaging-to-needle times between the two groups.
  • Both TNK and ALT groups had similar favorable outcomes at discharge.
Interpretation:

The transition to TNK is associated with shorter DTP times, likely due to its simplified single-bolus administration, making it a preferable option for LVO stroke patients requiring IVT and MT.

Limitations:
  • Retrospective design may introduce selection bias.
  • Data limited to three centers in Texas, which may not be generalizable.
Conclusion:

TNK is associated with reduced DTP times compared to ALT, while maintaining similar discharge outcomes, suggesting its potential as a preferred thrombolytic agent in LVO stroke treatment.

Original Source(s)

Transition to tenecteplase is associated with shorter door-to-puncture times: a retrospective study from the Lone Star Stroke consortium TNK registry

  • by Anqi Luo, Sujani Bandela, Gretchel Gealogo-Brown, Mark P. Goldberg, Andrew Slusher, Reza Behrouz, Alibay Jafarli, Siddarth Prasad, DaiWai Olson, Maria Denbow, Mehari Gebreyohanns, Asmiet Techan, Chethan P. Venkatasubba Rao, Jane A. Anderson, Barbara Kimmel, Anette Ovalle, Michele Patterson, Sean I. Savitz, Salvador Cruz-Flores, Steven Warach, Lee Birnbaum

  • May 4, 2026

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