To characterize the clinical presentation, echocardiographic features, management, and outcomes of neonates with isolated prenatal foramen ovale (FO) closure or restriction diagnosed after birth, emphasizing its rarity.
Key Findings:
Median gestational age was 39 weeks (range 36 + 4–41 + 1); median birth weight was 3,345 g (range 2,600–4,000 g).
All neonates presented within 9 hours after birth, with nine showing cyanosis and seven with respiratory distress.
Interpretation:
Isolated prenatal FO closure or restriction is a distinct condition causing severe neonatal PPHN and significant left ventricular failure, necessitating careful evaluation of the interatrial septum and highlighting the need for clinical awareness.
Limitations:
Small sample size of 10 neonates limits generalizability; retrospective design may introduce selection bias, impacting future research directions.
Conclusion:
Early recognition and hemodynamic support can lead to full recovery in the majority of cases, underscoring the importance of timely diagnosis.
