State of the art and future challenges of urethra-sparing stereotactic body radiotherapy for prostate cancer: a systematic review of literature - Summary - MDSpire
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State of the art and future challenges of urethra-sparing stereotactic body radiotherapy for prostate cancer: a systematic review of literature
To present a systematic review of the literature regarding urethra-sparing SBRT techniques for prostate cancer, with a focus on both oncological outcomes and urinary toxicity.
Key Findings:
Urethra-sparing techniques show variability in anatomical definition and dose constraints, with specific studies reporting acute GU toxicity rates ranging from 15% to 52%.
Dose escalation to dominant intraprostatic lesions was common, with varying degrees of toxicity reported, highlighting the need for careful dose management.
Interpretation:
The urethra is emerging as a critical organ at risk in SBRT for prostate cancer, necessitating refined techniques to minimize toxicity and improve patient outcomes.
Limitations:
Limited number of studies specifically addressing urethra-sparing SBRT, which may affect the generalizability of findings.
Variability in study designs and definitions of urethra-sparing techniques complicates comparisons and synthesis of results.
Conclusion:
Further research is needed to standardize urethra-sparing techniques and optimize outcomes in prostate cancer SBRT, emphasizing the importance of consistent definitions and methodologies.
