The Transdiagnostic Oncology Program (TOP): A Comprehensive Lifestyle Intervention Aimed at Enhancing Quality of Life for Cancer Survivors - A Pilot Study with Pre- and Post-Intervention Analysis in Primary Care - Summary - MDSpire

The Transdiagnostic Oncology Program (TOP): A Comprehensive Lifestyle Intervention Aimed at Enhancing Quality of Life for Cancer Survivors - A Pilot Study with Pre- and Post-Intervention Analysis in Primary Care

  • By

  • Sanne H. Booij

  • Amy Pieper

  • Christianne D. Wester

  • Ute Bültmann

  • Elkana C. Waarsenburg

  • H. J. Rogier Hoenders

  • November 10, 2025

  • 0 min

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Objective:

To investigate the feasibility and preliminary effectiveness of the Transdiagnostic Oncology Program (TOP), a primary care-led interdisciplinary aftercare program for cancer survivors, highlighting its potential to significantly improve their quality of life.

Key Findings:
  • TOP was found to be feasible in a primary care setting.
  • Improvements in quality of life were observed in the intervention group compared to the control group, with specific metrics indicating statistical significance.
  • Secondary outcomes such as happiness, fatigue, mental health, and work ability also showed improvement.
Interpretation:

The findings suggest that an interdisciplinary approach to aftercare can effectively enhance the quality of life for cancer survivors, addressing multiple clinical problems simultaneously, and align with existing literature on the benefits of comprehensive care.

Limitations:
  • The study design was not randomized, which may affect causal inference and introduce potential biases.
  • Limited financial and logistical resources constrained the study's scope.
Conclusion:

TOP shows promise as a feasible and effective intervention for improving quality of life in cancer survivors, warranting further research through a full randomized controlled trial, particularly focusing on specific components that yield the most benefit.

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