A network analysis of symptom clusters and core symptoms in colorectal cancer patients undergoing postoperative chemotherapy - Summary - MDSpire

A network analysis of symptom clusters and core symptoms in colorectal cancer patients undergoing postoperative chemotherapy

  • By

  • Bingbing Xiao

  • Wendan Jing

  • Jiayi Wang

  • Jing Zhao

  • Tingting Tan

  • Xiangzhen Liu

  • Qijun Lv

  • Hongyan Kou

  • May 6, 2026

  • 0 min

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Objective:

To identify symptom clusters in colorectal cancer patients after surgery and chemotherapy and determine core symptoms using network analysis for better symptom management strategies in clinical practice.

Key Findings:
  • Three symptom clusters identified: gastrointestinal-psychological, neurotoxicity, and CRC-specific.
  • 'Poor appetite' had the highest node strength (rs=1.362) and expected influence (re=1.362).
  • 'Nausea' exhibited the highest closeness (rc=0.007) and betweenness centrality (rb=48).
  • Fatigue had the highest incidence rate at 89.6%.
Interpretation:

The prominence of poor appetite and nausea in the symptom network highlights the need for targeted management strategies in clinical practice.

Limitations:
  • The study's cross-sectional design limits causal inferences.
  • The sample may not represent all colorectal cancer patients due to convenience sampling, potentially affecting the generalizability of the findings.
Conclusion:

Prioritizing management of poor appetite and nausea, along with addressing fatigue, may enhance the overall symptom experience for colorectal cancer patients.

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