To evaluate the outcomes of critically ill pediatric patients after haploidentical peripheral blood hematopoietic stem cell transplantation (haploPBSCT) who were admitted to the pediatric intensive care unit (PICU).
Key Findings:
30-day mortality rate was 33.3%.
In-hospital mortality rate was 50.8%.
Chronic graft-vs.-host-disease was associated with increased 30-day mortality (OR 4.515).
Ventilator use was an independent predictor of in-hospital mortality (OR 5.15).
Respiratory complications were the most common reason for PICU admission.
Interpretation:
The mortality rates observed in this study are comparable to those reported for allogenic PBSCT, highlighting the challenges faced by critically ill pediatric patients post-transplant.
Limitations:
Single-center study may limit generalizability.
Retrospective design may introduce bias in data collection.
Conclusion:
The study underscores the importance of monitoring respiratory complications and the potential impact of ventilator use on mortality in critically ill pediatric patients following haploPBSCT.
