Metastatic malignant melanoma presenting as bilateral acute mastitis in a lactating woman: a case report and literature review - Summary - MDSpire

Metastatic malignant melanoma presenting as bilateral acute mastitis in a lactating woman: a case report and literature review

  • By

  • Zilin Wang

  • Shaowu Zeng

  • Qiaorong Zhou

  • Jujiang Guo

  • July 6, 2026

  • 0 min

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Objective:

To report a case of bilateral acute mastitis in a postpartum woman that was ultimately diagnosed as metastatic malignant melanoma, highlighting diagnostic challenges.

Approach:
  • Case Presentation: A 36-year-old postpartum woman presented with bilateral breast swelling and erythema, initially misdiagnosed as severe lactational mastitis.
  • Diagnostic Evaluation: Comprehensive evaluation, including imaging and biopsy, revealed diffusely metastatic malignant melanoma originating from a previously excised benign nevus.
Key Findings:
  • Bilateral breast metastasis from malignant melanoma is exceptionally rare in postpartum women.
  • Initial presentation can mimic severe lactational mastitis, leading to misdiagnosis.
  • The patient exhibited rapid disease progression and poor response to treatment.
Interpretation:

This case highlights the diagnostic challenges of identifying metastatic disease in atypical breast presentations.

Limitations:
  • The rarity of bilateral breast metastasis limits generalizability.
  • Normal postpartum physiological changes can complicate the diagnosis of metastatic melanoma.
Conclusion:

This case illustrates the diagnostic challenges of metastatic melanoma presenting as lactational mastitis and the importance of thorough history-taking and examination.

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