Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus - Summary - MDSpire

Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus

  • By

  • Ana Laura Hernández-Ledesma

  • Evelia Lorena Coss-Navarrete

  • Sofia Salazar-Magaña

  • Diego Ramírez-Espinosa

  • Lizbet Tinajero-Nieto

  • Estefania Torres-Valdez

  • Angélica H. Peña-Ayala

  • Guillermo Félix-Rodriguez

  • Gabriel Frontana-Vázquez

  • Jair Santiago García Sotelo

  • Morgane Thomas-Chollier

  • Gosia Trynka

  • Florencia Rosetti

  • Selene L. Fernandez-Valverde

  • María Gutiérrez-Arcelus

  • Deshiré Alpízar-Rodríguez

  • Alejandra Medina-Rivera

  • June 2, 2026

  • 0 min

Share

Objective:

To analyze the transcriptional profiles of dendritic cells derived from monocytes of individuals with systemic lupus erythematosus (SLE) and healthy controls to identify disruptions in tolerance-associated pathways.

Key Findings:
  • Interferon stimulated genes (ISGs) were dominant markers, particularly enriched in monocytes.
  • Key ISGs such as IFI27, IFI44L, USP18, and IFI6 acted as central hubs in regulatory networks.
  • In tolDCs from SLE donors, lipid metabolism pathways were altered, indicating impaired synthesis of pro-resolving lipid mediators.
  • Diminished IL10RA expression and dysregulated IRF4 activity in SLE moDCs indicated defects in IL-10 mediated tolerogenic differentiation.
Interpretation:

Remove or rephrase to eliminate unsupported conclusions.

Limitations:
  • The study primarily focuses on in vitro derived moDCs, which may not fully replicate ex vivo dendritic cell behavior.
Conclusion:

Revise to focus solely on findings without implications.

Original Source(s)

Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus

  • by Ana Laura Hernández-Ledesma, Evelia Lorena Coss-Navarrete, Sofia Salazar-Magaña, Diego Ramírez-Espinosa, Lizbet Tinajero-Nieto, Estefania Torres-Valdez, Angélica H. Peña-Ayala, Guillermo Félix-Rodriguez, Gabriel Frontana-Vázquez, Jair Santiago García Sotelo, Morgane Thomas-Chollier, Gosia Trynka, Florencia Rosetti, Selene L. Fernandez-Valverde, María Gutiérrez-Arcelus, Deshiré Alpízar-Rodríguez, Alejandra Medina-Rivera

  • June 2, 2026

Related Content

Expression characteristics of C-reactive protein in autoimmune diseases and their complications

Editorial: Community series in towards precision medicine for immune-mediated disorders: advances in using big data and artificial intelligence to understand heterogeneity in inflammatory responses, volume III

Research advances in connective tissue disease-associated pulmonary arterial hypertension with an emphasis on the Chinese population