Roswell Park Study: Inhibiting Regulator Protein Can Make Aggressive Prostate Cancers More Vulnerable - Summary - MDSpire
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Roswell Park Study: Inhibiting Regulator Protein Can Make Aggressive Prostate Cancers More Vulnerable

Team shows BCL-2 promotes treatment resistance, uncovering strategy for making tumors respond to treatment.

  • May 11, 2026

  • 4 min

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Researchers at Roswell Park Comprehensive Cancer Center have identified how the BCL-2 protein affects treatment resistance in aggressive prostate cancer. Led by Dean Tang, the study published in 'Signal Transduction Targeted Therapy' reveals that combining the BCL-2 inhibitor venetoclax with androgen blockers can improve tumor responsiveness. This research overturns previous uncertainties surrounding BCL-2's role in castration-resistant prostate cancer and lays the groundwork for novel combination therapies to enhance patient outcomes.

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Roswell Park Study: Inhibiting Regulator Protein Can Make Aggressive Prostate Cancers More Vulnerable

  • May 11, 2026

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