Neonatal CD19+B220lo cells sense microbiota via TLR2/4 activation driving proliferation and differentiation - Summary - MDSpire

Neonatal CD19+B220lo cells sense microbiota via TLR2/4 activation driving proliferation and differentiation

  • By

  • Carolina Ruiz-Sánchez

  • Isabel Cortegano

  • Mercedes Rodríguez

  • Rodrigo Sanchez-Tarjuelo

  • Alejandro Arrabal

  • M. Carmen Prado

  • Mario Alia

  • M.Pilar Jiménez

  • Victor Manuel Lopez Molina

  • Sara Monzón

  • Victoria López-Alonso

  • Belén de Andrés

  • Maria-Luisa Gaspar

  • June 19, 2026

  • 0 min

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Objective:

To investigate the role of neonatal CD19+B220lo B cells in the respiratory tract and their response to microbiota via TLR2 and TLR4 activation.

Approach:
    Key Findings:
    • Antibiotic treatment reduced the number of CD19+B220lo B cells and altered their VH immunoglobulin repertoire.
    • In vitro activation led to the generation of CD138+ cells and the release of IgM, IgG1, and small amounts of IgA.
    • Higher frequencies of CD138+ cells were observed in both CD19+B220lo and CD19+B220hi populations after TLR2/TLR1 stimulation.
    • Lung cultures exhibited an inflammatory cytokine profile, while spleen cultures showed a regulatory profile.
    Interpretation:

    Neonatal lung and spleen CD19+B220lo cells can sense microbiota through TLR2 and TLR4, promoting their activation and differentiation.

    Conclusion:

    The study emphasizes the role of neonatal B cell populations in responding to microbiota, which may influence immune responses in the lungs.

Original Source(s)

Neonatal CD19+B220lo cells sense microbiota via TLR2/4 activation driving proliferation and differentiation

  • by Carolina Ruiz-Sánchez, Isabel Cortegano, Mercedes Rodríguez, Rodrigo Sanchez-Tarjuelo, Alejandro Arrabal, M. Carmen Prado, Mario Alia, M.Pilar Jiménez, Victor Manuel Lopez Molina, Sara Monzón, Victoria López-Alonso, Belén de Andrés, Maria-Luisa Gaspar

  • June 19, 2026

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