Future landscapes of women’s hormone-sensitive cancers: unraveling global trends, age stratification, and regional inequities (1990–2035) - Summary - MDSpire
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Future landscapes of women’s hormone-sensitive cancers: unraveling global trends, age stratification, and regional inequities (1990–2035)
To assess the global burden of hormone-sensitive cancers (HSCs) among women, focusing on incidence, mortality, and regional disparities from 1990 to 2021, with projections starting from 2021 to 2035.
Key Findings:
The reproductive age group showed the fastest increase in ASIR for HSCs (EAPC = 0.44).
Breast cancer was the dominant HSC subtype in 2021, with ASIRs increasing with higher socio-demographic index (SDI).
Dietary risks, alcohol use, and tobacco were leading contributors to breast cancer burden.
Lower SDI countries face faster-growing rates of HSCs compared to higher SDI countries.
ASDR and ASDiR showed a decrease across all age groups, with specific EAPC values provided.
Interpretation:
The global burden of HSCs is increasing, with significant age and regional disparities in incidence and mortality, particularly in lower SDI countries, highlighting the need for targeted public health policies.
Limitations:
Potential underreporting of HSC cases in low-resource settings may skew results.
Variability in data quality and healthcare access across regions could impact the reliability of findings.
Conclusion:
The trends in HSCs are likely to continue through 2035, necessitating targeted interventions, such as improved screening and treatment access, to address disparities and improve outcomes for women globally.
