Objective:

To investigate factors influencing cough resolution following endoscopic minimally invasive treatment in patients with gastroesophageal reflux disease (GERD) complicated by chronic cough, and to establish a predictive model for preoperative patient screening and personalized treatment decision-making based on these findings.

Key Findings:

• Cough non-relief group had higher age, smoking history, cough duration, ineffective esophageal motility, DeMeester score, pepsin, and FeNO levels, and lower SIgA levels compared to the cough-relief group, with all differences being statistically significant (P < 0.05).
• Seven common risk factors identified: age, cough duration, ineffective esophageal motility, DeMeester score, pepsin, FeNO, and SIgA, with specific odds ratios indicating their significance.
• Ineffective esophageal motility, cough duration, DeMeester score, pepsin, and FeNO were significant risk factors for persistent cough post-treatment, while SIgA was identified as a protective factor.

Interpretation:

The nomogram model based on identified risk factors shows good predictive efficacy for clinical treatment outcomes in GERD patients with chronic cough, suggesting its potential utility in guiding treatment decisions.

Limitations:

• Retrospective design may introduce selection bias.
• Single-center study limits generalizability of findings.
• Potential confounding factors not accounted for in the analysis.

Conclusion:

Independent risk factors influencing persistent cough after endoscopic minimally invasive treatment in GERD patients include ineffective esophageal motility, cough duration, DeMeester score, SIgA, pepsin, and FeNO, highlighting the need for tailored treatment approaches.