Objective:

To investigate the clinical characteristics and electromyographic findings of a patient with acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG) overlapping with Kennedy’s disease (KD), aiming to improve clinicians’ recognition of this rare overlap syndrome and explore potential comorbid mechanisms.

Approach:

Key Findings:

• The patient was definitively diagnosed with overlap syndrome of AChR antibody-positive MG and KD, highlighting the rarity of this condition.
• Neurophysiological findings and androgen receptor gene testing results were consistent with a diagnosis of KD.
• Only four previously reported cases of KD patients exhibiting myasthenic features were identified, all AChR antibody-negative, underscoring the uniqueness of this case.

Interpretation:

The coexistence of MG and KD in the same patient is exceptionally rare.

Limitations:

• The study is based on a single case report, limiting generalizability.
• Limited existing literature on the overlap syndrome restricts comprehensive understanding.

Conclusion:

The findings enhance recognition of this overlap syndrome and discuss possible comorbid mechanisms, emphasizing the need for awareness in clinical practice.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.