CXCL10 rs8878 identifies a genotype-associated immune phenotype linked to T-lymphocyte preservation and survival in sepsis - Summary - MDSpire

CXCL10 rs8878 as a Genetic Marker for Immune Phenotypes Associated with T-Lymphocyte Maintenance and Survival in Sepsis

  • By

  • Birte Dyck

  • Andrea Witowski

  • Thilo Bracht

  • Malte Bayer

  • Patrick Thon

  • Dominik Ziehe

  • Tim Rahmel

  • Matthias Unterberg

  • Britta Westhus

  • Lars Palmowski

  • Hartmuth Nowak

  • Stefan Felix Ehrentraut

  • Jennifer Orlowski

  • Alexander von Busch

  • Alexander Zarbock

  • Nina Babel

  • Moritz Anft

  • Dietrich Henzler

  • Michael Adamzik

  • Lars Bergmann

  • Barbara Sitek

  • Björn Koos

  • Katharina Rump

  • July 17, 2026

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Objective:

To investigate the association between CXCL10 rs8878 genotype, circulating T lymphocyte counts, and 30-day survival outcomes in septic patients.

Approach:
  • Study Design: A prospective cohort study involving 278 septic patients, analyzing CXCL10 rs8878 genotypes, immune cell counts, cytokine concentrations, and CXCL10 expression.
  • Data Analysis: Group comparisons, Kaplan-Meier analyses, and correlation analyses were performed to assess associations between genotype, immune parameters, and survival.
Key Findings:
  • CXCL10 rs8878 AA genotype carriers had higher circulating T cell counts and improved survival compared to G-allele carriers, based on statistical analyses.
  • Higher total and CD8+ T cell counts were significantly associated with improved survival, as determined by the study.
  • In non-survivors, AA-genotype carriers exhibited increased CXCL10 mRNA expression, indicating a potential link between genotype and immune response.
  • CXCL10 concentrations on day 1 correlated positively with several inflammatory cytokines and inversely with total T cell counts, suggesting a relationship between CXCL10 and immune dynamics.
Interpretation:

The CXCL10 rs8878 genotype is associated with T cell dynamics and 30-day survival in sepsis.

Limitations:
  • No significant associations were observed between CXCL10 genotype and plasma proteomics or routine clinical parameters.
Conclusion:

CXCL10 may serve as a biomarker for risk stratification in sepsis.

Original Source(s)

CXCL10 rs8878 identifies a genotype-associated immune phenotype linked to T-lymphocyte preservation and survival in sepsis

  • by Birte Dyck, Andrea Witowski, Thilo Bracht, Malte Bayer, Patrick Thon, Dominik Ziehe, Tim Rahmel, Matthias Unterberg, Britta Westhus, Lars Palmowski, Hartmuth Nowak, Stefan Felix Ehrentraut, Jennifer Orlowski, Alexander von Busch, Alexander Zarbock, Nina Babel, Moritz Anft, Dietrich Henzler, Michael Adamzik, Lars Bergmann, Barbara Sitek, Björn Koos, Katharina Rump

  • July 17, 2026

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