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At-Home Transcranial Direct Current Stimulation Combined With Gamified Cognitive Control Training for Depression: A Study

  • By

  • Esther Dechantsreiter

  • Frank Padberg

  • Yuval Benjamini

  • Stephan Goerigk

  • Linda Rubene-Kesele

  • Liene Konosonoka

  • Ulrike Vogelmann

  • Tamar Cohen

  • Naamah Lerner

  • Gerrit Burkhardt

  • Aldo Soldini

  • Fabienne Windel

  • Marios Fanourakis

  • Zeno Menestrina

  • Arthur Nguyen

  • Angela Pasqualotto

  • Takuya Morishita

  • Amir Dotan

  • Shira Ahissar

  • Alon Morash

  • Jonas Björklund

  • Lucia Bulubas

  • Daniel Keeser

  • Netta Assa

  • Rémy Gardier

  • Roser Viñals

  • Jean-Philippe Thiran

  • Ronen Segman

  • Omer Bonne

  • Amit Lotan

  • Friedhelm C. Hummel

  • Elmars Rancans

  • Daphne Bavelier

  • Mor Nahum

  • October 19, 2026

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Objective:

To assess the feasibility, safety, and efficacy of home-based transcranial direct current stimulation (tDCS) combined with gamified cognitive control training (CCT) in adults with major depressive disorder (MDD). The authors hypothesized that home administration would be feasible and safe and, as a secondary hypothesis, that depressive symptoms would decrease more with the combined intervention than with double-sham treatment.

Approach:
  • Design: DiSCoVeR was a 6-week, multicenter, double-masked, sham-controlled randomized clinical trial conducted at three university hospitals. It used a feasibility framework with a primary outcome and a superiority framework with a secondary outcome.
  • Intervention: After on-site onboarding, participants received treatment remotely at home. The superiority comparison was between a double-active intervention and a double-sham control.
  • Participants and allocation: Eligible participants were adults aged 18–65 years with MDD as their primary diagnosis, a 17-item Hamilton Depression Rating Scale score of at least 13, and a depressive episode lasting 4 weeks to 5 years. Participants were randomized 1:1, with allocation stratified by site and symptom severity.
Key Findings:
  • The supplied context describes the study rationale, hypotheses, and design but does not provide trial outcome results.
Interpretation:

The trial was designed to assess the feasibility and safety of home-based tDCS combined with gamified CCT and, as a secondary objective, compare depressive symptom change between the double-active and double-sham groups.

Limitations:
  • The supplied context does not provide participant numbers, outcome data, adverse-event results, or study conclusions.
Sources:

Original Source(s)

Home Transcranial Direct Current Stimulation With Gamified Cognitive Control Training for Depression: A

  • by Esther Dechantsreiter, Frank Padberg, Yuval Benjamini, Stephan Goerigk, Linda Rubene-Kesele, Liene Konosonoka, Ulrike Vogelmann, Tamar Cohen, Naamah Lerner, Gerrit Burkhardt, Aldo Soldini, Fabienne Windel, Marios Fanourakis, Zeno Menestrina, Arthur Nguyen, Angela Pasqualotto, Takuya Morishita, Amir Dotan, Shira Ahissar, Alon Morash, Jonas Björklund, Lucia Bulubas, Daniel Keeser, Netta Assa, Rémy Gardier, Roser Viñals, Jean-Philippe Thiran, Ronen Segman, Omer Bonne, Amit Lotan, Friedhelm C. Hummel, Elmars Rancans, Daphne Bavelier, Mor Nahum

  • October 19, 2026

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