Objective:

To highlight recent advances in chicken B cell development and peripheral B cell biology.

Approach:

Key Findings:

• EIV-E12+ cells are identified as novel lymphoid tissue inducers for bursal folliculogenesis.
• A CXCR4/CXCL12 axis regulates B cell migration within the BF.
• The chB6 alloantigen plays a significant role in B cell fate during development.
• The ADLib system allows for the generation of a library of antibody specificities and has applications in humanized antibodies.
• Convergent BCR responses are influenced by vaccination or infection routes.

Interpretation:

Limitations:

• Limited knowledge on the full range of cell surface proteins involved in B cell communication.
• Further research is needed to fully understand the mechanisms of B cell migration and repertoire changes.

Conclusion:

Attribution Notice

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