To investigate the diagnostic value of the PRIMARY score in 18F-PSMA-1007 PET/CT for prostate cancer (PCa), compare its diagnostic efficacy with maximum standardized uptake value (SUVmax), and explore the value of their combined model.
Key Findings:
The PRIMARY score showed excellent interobserver agreement (Kappa = 0.903).
AUCs for PCa diagnosis were 0.921 (SUVmax), 0.960 (PRIMARY score), and 0.963 (combined index PRE), indicating the combined model's superior diagnostic capability.
The combined criterion (PRIMARY = 4 and SUVmax ≥ 7.5) improved positive predictive value for csPCa.
Interpretation:
The PRIMARY score is comparable to SUVmax in diagnostic efficacy and offers excellent reproducibility, while the combined PRE model enhances diagnostic accuracy for gray-zone lesions, making it a valuable tool in clinical practice.
Limitations:
Single-center study may limit generalizability.
Retrospective design may introduce selection bias, affecting data reliability.
Conclusion:
The PRIMARY score and combined PRE model optimize biopsy decisions and patient management in suspected PCa cases.
