To characterize global and regional myocardial strain in patients with mitral valve prolapse (MVP) using cardiac magnetic resonance feature tracking (CMR-FT), compared with controls without apparent heart disease.
Approach:
Design and population: Retrospective, single-institution study of adults imaged from 2013 to 2022. Patients were included if cine images showed MVP; controls came from five earlier prospective studies and were reviewed to confirm absence of MVP.
Eligibility: Both groups excluded people with specified cardiac conditions, including coronary disease, moderate or severe valvular disease, LVEF below 50%, prior myocardial infarction or myocarditis, and previous cardiac surgery or ablation.
Strain assessment: CMR-FT was selected to assess global and regional longitudinal strain, including LV segments, the right ventricle, and the left atrium. The supplied context does not include the imaging-analysis details or study results.
Interpretation:
The provided article context describes the study rationale and methods but does not report its findings.
Limitations:
The supplied context ends during the CMR imaging methods and contains no results or discussion.
The study was retrospective and conducted at one institution.
Conclusion:
The study was designed to examine how MVP-related mechanical features, including basal-segment abnormalities, are reflected in CMR-FT strain measurements.
by Jeffrey Ji-Peng Li, Shing Ching, Annette Aigner, Frank Edelmann, Stefanie Maria Werhahn, Rebecca Beyer, Jeanette Schulz-Menger, Jennifer Erley, Misael Estepa, Cyrill Meuwly, Ann-Sophie Eggers, Christian Stehning, Djawid Hashemi, Natalia Solowjowa, Christoph Klein, Ingo Hilgendorf, Sebastian Kelle, Patrick Doeblin
In adults diagnosed with pulmonary arterial hypertension within the previous year, adding sotatercept to background therapy reduced the risk of clinical worsening events by 76% compared with placebo.
