To introduce the CURE framework for managing chronic inflammation through a phase-based therapeutic model, emphasizing proactive immune stabilization.
Approach:
Key Findings:
Chronic inflammation is maintained by cytokine redundancy and self-reinforcing feedback loops.
The CURE framework emphasizes the importance of therapeutic intensity and duration in managing chronic inflammation, highlighting the complexity of immune responses.
Durable disease control may depend on suppressing feedback-driven immune networks below clinically relevant thresholds.
Interpretation:
CURE provides a mechanism-oriented framework for personalized intervention in chronic inflammation, focusing on proactive immune stabilization tailored to individual patient needs.
Limitations:
The framework does not imply curative eradication of chronic inflammatory diseases.
Illustrative scenarios are not intended as a diagnostic taxonomy.
Further empirical validation of the framework is needed.
Conclusion:
CURE reframes disease management from reactive symptom suppression to proactive, phase-specific immune stabilization, emphasizing a systems perspective.
