To investigate the interaction effect between depressive symptoms and social support on the presence of frailty in patients with CHF.
Approach:
Study Design: A cross-sectional study was conducted among 380 patients with CHF using questionnaires and scales to collect data.
Data Collection: Utilized the Patient Health Questionnaire-9 (PHQ-9), Social Support Rating Scale (SSRS), and FRAIL Scale.
Statistical Analysis: Logistic regression and interaction analyses were performed to evaluate correlations and interactions.
Key Findings:
The prevalence of frailty among participants was 41.3%.
Depressive symptoms (OR = 7.37, 95% CI: 4.29–12.63) and low social support (OR = 5.88, 95% CI: 3.57–10.00) were significantly associated with frailty.
A significant multiplicative interaction was found (OR = 0.23, 95% CI: 0.08–0.66).
Additive interaction analysis confirmed a synergistic effect (RERI = 19.19, 95% CI: 9.64–46.94; AP = 0.84, 95% CI: 0.72–0.92; S = 8.29, 95% CI: 4.19–37.19).
Interpretation:
Depressive symptoms and social support are significantly associated with frailty in CHF patients, with their interaction showing a synergistic pattern.
Limitations:
The study was conducted at a single center, limiting generalizability.
The sample was predominantly male, which may affect the applicability of findings to female patients.
Conclusion:
Longitudinal studies are warranted to explore the temporal nature of the associations between depressive symptoms, social support, and frailty.
