Prospective randomised controlled trial to compare tissue reactions and scarring with polypropylene versus polyglactin 910 sutures in periocular skin - Summary - MDSpire
Advertisement
Prospective randomised controlled trial to compare tissue reactions and scarring with polypropylene versus polyglactin 910 sutures in periocular skin
To compare the histopathological reaction and clinical scarring resulting from Prolene and Vicryl sutures in patients undergoing surgery for involutional entropion.
Approach:
Study Design: A prospective, randomized, triple-masked clinical study conducted across two sites from 2021 to 2024.
Participants: Consecutive patients over 18 years with involutional entropion and significant horizontal lid laxity were included.
Suture Materials: 6–0 gauge MPV489 Vicryl and MPP8697 Prolene were used for the study.
Surgical Technique: Patients received three everting sutures followed by definitive surgery one month later, with histological analysis of the tissue reaction.
Key Findings:
Histological tissue inflammatory reaction may be less with Prolene than Vicryl in the short term.
Long-term clinical scarring is very good with both sutures in eyelid skin.
Some patients developed clinical 'granuloma' to Vicryl, which may require further surgery.
Interpretation:
In patients more prone to significant scarring, using Prolene may reduce the risk of a significant inflammatory response compared to Vicryl.
Limitations:
The study was limited to patients with involutional entropion and may not be generalizable to other conditions.
The follow-up period for assessing long-term scarring was not specified.
Conclusion:
Both Prolene and Vicryl sutures show good long-term clinical outcomes.
