To evaluate the association between the activities of coagulation factors VII, IX, XI, and XII and 90-day outcomes in ischemic and hemorrhagic strokes, highlighting the significance of these outcomes.
Key Findings:
171 patients were included in the final analysis.
Hemorrhagic stroke patients were younger and had higher stroke severity compared to ischemic stroke patients.
In ischemic stroke, higher FXI and FXII activity levels were associated with unfavorable prognosis (p < 0.05), but these associations disappeared after adjustment.
In hemorrhagic stroke, lower FVII and FIX activity, and higher FXI and FXII activity were associated with unfavorable prognosis (p < 0.05).
After adjustment, FVII and FIX activity were negatively associated with unfavorable prognosis (p < 0.05), while FXII activity was positively associated (p < 0.05).
Interpretation:
Early coagulation factor activity showed subtype-specific associations with 90-day functional outcome, particularly in hemorrhagic stroke, suggesting potential for targeted therapeutic strategies.
Limitations:
The study is retrospective and may be subject to selection bias.
The sample size may limit the generalizability of the findings, and potential confounding factors were not fully controlled.
Conclusion:
The study highlights the distinct prognostic value of coagulation factors in different stroke types, emphasizing the need for tailored clinical approaches.
