Longitudinal Study of Plasma Metabolites During Menopause and Their Associations With Later Onset of Metabolic Syndrome - Summary - MDSpire
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Long-Term Analysis of Plasma Metabolite Changes During Menopause and Their Links to Subsequent Development of Metabolic Syndrome

  • By

  • Atsuko Miyake

  • Miho Iida

  • Sei Harada

  • Daisuke Sugiyama

  • Minako Matsumoto

  • Naoko Miyagawa

  • Ryota Toki

  • Shun Edagawa

  • Aya Hirata

  • Kazuyo Kuwabara

  • Tomonori Okamura

  • Asako Sato

  • Kaori Amano

  • Akiyoshi Hirayama

  • Masahiro Sugimoto

  • Tomoyoshi Soga

  • Masaru Tomita

  • Kazuharu Arakawa

  • Iori Kisu

  • Wataru Yamagami

  • Toru Takebayashi

  • December 13, 2025

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Objective:

To investigate longitudinal changes in circulating metabolites during menopause and assess their associations with subsequent metabolic syndrome (MetS) development, highlighting the significance of these changes in women's health.

Key Findings:
  • Eighteen metabolites changed significantly with menopause, particularly those related to BCAA metabolism, urea cycle, and homocysteine metabolism (p < 0.05).
  • 65 out of 695 women without MetS at baseline developed MetS during follow-up.
  • Glutamate was associated with a higher risk of MetS (odds ratio: 1.95, 95% CI: 1.49-2.57).
  • Higher levels of glutamate, valine, leucine, and cystine were linked to the development of hyperglycemia.
Interpretation:

Longitudinal changes in charged metabolites occur during menopause, with specific metabolites like glutamate potentially contributing to metabolic alterations that increase MetS risk, emphasizing the need for monitoring these changes in clinical settings.

Limitations:
  • The study may not account for all confounding factors influencing metabolic changes, including lifestyle factors.
  • The cohort is limited to a specific geographic area, which may affect generalizability and the applicability of findings to broader populations.
Conclusion:

Understanding the metabolic changes during menopause can help identify women at risk for MetS and guide interventions, underscoring the importance of early detection and management strategies.

Original Source(s)

Longitudinal Study of Plasma Metabolites During Menopause and Their Associations With Later Onset of Metabolic Syndrome

  • by Atsuko Miyake, Miho Iida, Sei Harada, Daisuke Sugiyama, Minako Matsumoto, Naoko Miyagawa, Ryota Toki, Shun Edagawa, Aya Hirata, Kazuyo Kuwabara, Tomonori Okamura, Asako Sato, Kaori Amano, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Kazuharu Arakawa, Iori Kisu, Wataru Yamagami, Toru Takebayashi

  • December 13, 2025

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