Causes of Excess Deaths in the US Compared With Other High-Income Countries - Summary - MDSpire

Causes of Excess Deaths in the US Compared With Other High-Income Countries

  • By

  • Jacob Bor

  • Rafeya V. Raquib

  • David Himmelstein

  • Steffie Woolhandler

  • Andrew C. Stokes

  • May 8, 2026

  • 0 min

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Objective:

To quantify the causes of excess mortality in the US compared to other high-income countries (HICs) and identify potential avenues for prevention, focusing on specific metrics such as excess deaths and years of life lost.

Key Findings:
  • From 1999 to 2022, the US had 12,675,646 more deaths than expected based on HIC mortality rates, indicating a significant public health crisis.
  • The annual number of excess US deaths increased steadily until 2019 and surged during the COVID-19 pandemic, highlighting the urgent need for intervention.
  • By 2022, all-cause mortality rates in the US were 1.38 times higher than the average of other HICs, suggesting systemic health disparities.
Interpretation:

The significant excess mortality in the US highlights critical public health issues and suggests the need for targeted interventions to address specific causes of death.

Limitations:
  • The study is observational and may not account for all confounding factors, which could lead to an underestimation or overestimation of excess mortality.
  • Data quality and completeness may vary across countries, potentially affecting the reliability of cross-national comparisons.
Conclusion:

Addressing the identified causes of excess mortality, such as drug poisonings and circulatory diseases, could potentially reduce the number of preventable deaths in the US.

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