The association between the sodium-potassium ratio and ICU mortality in cardiac arrest patients: an analysis of the eICU database - Summary - MDSpire

The association between the sodium-potassium ratio and ICU mortality in cardiac arrest patients: an analysis of the eICU database

  • By

  • Yuyuan Wang

  • Xin Yuan

  • Dongxia Wang

  • Mingli Li

  • Ruihua Wang

  • June 5, 2026

  • 0 min

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Objective:

To investigate the association between the serum Na+/K+ ratio in patients following cardiac arrest and the risk of ICU mortality, highlighting its potential significance as a prognostic marker.

Key Findings:
  • A U-shaped association was observed between the Na+/K+ ratio and ICU mortality, with higher Na+/K+ ratio significantly associated with reduced ICU mortality (adjusted OR = 0.75; 95% CI: 0.64–0.89), suggesting important clinical implications for risk assessment.
Interpretation:

The study identified a marked U-shaped relationship between the serum Na+/K+ ratio and ICU mortality among cardiac arrest patients.

Limitations:
  • The study is observational and may be subject to confounding factors, including potential biases inherent in such studies. Data is limited to a single database, which may affect generalizability.
Conclusion:

Routine assessment of the Na+/K+ ratio could facilitate risk stratification and inform clinical management, but further research is needed to validate these findings.

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