Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers - Summary - MDSpire
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Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers
To evaluate the association between zinc homeostasis dysregulation and acute ischemic stroke in elderly patients through a multidimensional analysis.
Key Findings:
Stroke patients had significantly lower serum zinc and MT-1 levels compared to controls.
Elevated FADS1 activity index and increased 8-OHdG levels were observed in stroke patients.
Inflammatory and oxidative stress markers were significantly altered in stroke patients.
Serum zinc positively correlated with MT-1 and negatively with 8-OHdG.
The combined biomarker panel achieved superior discriminative performance (AUC = 0.970).
Interpretation:
Zinc homeostasis dysregulation is associated with ischemic stroke in elderly patients, characterized by reduced circulating zinc and MT-1 levels, elevated FADS1 activity, and oxidative DNA damage.
Limitations:
Retrospective design may limit causal inferences.
Study conducted at a single center may affect generalizability.
Potential confounding factors not fully controlled.
Conclusion:
A multidimensional biomarker panel integrating zinc metabolism, lipid signaling, and DNA integrity markers may be useful for characterizing the pathophysiological profile of ischemic stroke in elderly patients.
