FibroScan-AST Score vs Liver Stiffness for the Prediction of Liver Events After HCV Cure - Summary - MDSpire

FibroScan-AST Score vs Liver Stiffness for the Prediction of Liver Events After HCV Cure

  • By

  • Anaïs Corma-Gómez

  • Diana Corona-Mata

  • Jésica Martín-Carmona

  • María José Galindo

  • Angela Camacho

  • Carmen Martín-Sierra

  • Marina Gallo-Marín

  • Pilar Rincón

  • Ignacio Perez-Valero

  • Margarita Pérez-García

  • Angela Carrasco-Dorado

  • Juan A Pineda

  • Antonio Rivero-Juárez

  • Antonio Rivero

  • Luis M Real

  • Juan Macías

  • on behalf of the GEHEP-011 Study Group

  • April 8, 2025

  • 0 min

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Objective:

To compare the predictive capacity of liver stiffness (LS) versus the FibroScan-AST (FAST) score for liver complications in patients with hepatitis C virus (HCV) infection after achieving sustained virological response (SVR), highlighting the clinical significance of this comparison.

Key Findings:
  • Out of 300 patients, 36 (12%) developed liver complications after a median follow-up of 73 months, with statistical significance noted.
  • LS was independently associated with increased risk of liver complications (sHR, 1.06; P < .001), emphasizing its predictive value.
  • FAST score ≥0.35 was also independently associated with greater risk of liver complications (sHR, 8.12; P < .001), indicating its relevance.
  • The area under the receiver operating characteristics curve for LS was 0.83, while for FAST it was 0.80 (P = .158), indicating no significant difference in predictive capacity.
Interpretation:

Both LS and FAST score can predict liver complications post-SVR, but LS remains a strong predictor without significant improvement from the FAST score, which has important implications for clinical practice.

Limitations:
  • The study was limited to patients with LS ≥9.5 kPa, which may not represent all HCV patients, and potential biases or confounding factors should be considered.
  • The predictive capacity of FAST may not be superior to LS at the time point of SVR, warranting further investigation.
Conclusion:

While the FAST score can predict liver events after SVR, it does not enhance the predictive ability of LS alone at this time point, underscoring the need for careful patient management.

Original Source(s)

FibroScan-AST Score vs Liver Stiffness for the Prediction of Liver Events After HCV Cure

  • by Anaïs Corma-Gómez, Diana Corona-Mata, Jésica Martín-Carmona, María José Galindo, Angela Camacho, Carmen Martín-Sierra, Marina Gallo-Marín, Pilar Rincón, Ignacio Perez-Valero, Margarita Pérez-García, Angela Carrasco-Dorado, Juan A Pineda, Antonio Rivero-Juárez, Antonio Rivero, Luis M Real, Juan Macías, on behalf of the GEHEP-011 Study Group

  • April 8, 2025

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