High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis - Summary - MDSpire

High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis

  • By

  • Kristoffer Grundtvig Skaarup

  • Mats C. H. Lassen

  • Kaveh Hosseini

  • Niklas Dyrby Johansen

  • Matthew M. Loiacono

  • Rebecca C. Harris

  • Sandrine I. Samson

  • Arto A. Palmu

  • Kevin McConeghy

  • Stefan Gravenstein

  • Orly Vardeny

  • Brian Claggett

  • Scott D. Solomon

  • Federico Martinón-Torres

  • Tor Biering-Sørensen

  • May 26, 2026

  • 0 min

Share

Objective:

To summarize findings from randomized clinical trials comparing high-dose inactivated influenza vaccine (HD-IIV) with standard-dose inactivated influenza vaccine (SD-IIV) for prevention of hospitalization events and mortality among older adults.

Key Findings:
  • HD-IIV was associated with reductions in hospitalizations for pneumonia or influenza and for all causes compared with SD-IIV.
  • The meta-analysis included nearly 500,000 randomized participants, expanding the evidence base significantly.
Interpretation:

Remove or rephrase to eliminate unsupported conclusions.

Limitations:
  • Exclusion of trials conducted during influenza pandemics due to potential mismatches with circulating strains.
  • Potential bias in trials included in the analysis.
Conclusion:

Rephrase to reflect findings without editorial interpretation.

Original Source(s)

High-Dose vs Standard-Dose Influenza Vaccines in Older Adults: A Meta-Analysis

  • by Kristoffer Grundtvig Skaarup, Mats C. H. Lassen, Kaveh Hosseini, Niklas Dyrby Johansen, Matthew M. Loiacono, Rebecca C. Harris, Sandrine I. Samson, Arto A. Palmu, Kevin McConeghy, Stefan Gravenstein, Orly Vardeny, Brian Claggett, Scott D. Solomon, Federico Martinón-Torres, Tor Biering-Sørensen

  • May 26, 2026

Related Content

HPV Vaccine Uptake Varied Widely Across US States

Analysis of more than 16,000 US adolescents found substantial variation in HPV vaccination uptake both across and within census regions

Cervical Cancer Trends Differ by Age

Recent declines among women younger than 35 years contrasted with rising long-term incidence among women aged 35 to 49 years in Puerto Rico

Effectiveness of Nirmatrelvir/Ritonavir for Outpatients in the Era of Omicron, Vaccination, and Previous Infection: A Meta-analysis