Prospective real-world implementation of deep learning systems in healthcare: a systematic review guided by implementation science - Summary - MDSpire

Prospective real-world implementation of deep learning systems in healthcare: a systematic review guided by implementation science

  • By

  • Rachel Marjorie Wei Wen Tseng

  • Li Cheng Ong

  • Jocelyn Hui Lin Goh

  • Yibing Chen

  • Tina Chen

  • Elaine Lum

  • Yih-Chung Tham

  • January 23, 2026

  • 0 min

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Objective:

To systematically map the implementation strategies and outcomes of prospective deep learning (DL) implementation studies in healthcare, focusing on specific strategies such as stakeholder engagement and workflow integration.

Key Findings:
  • 20 articles were included, covering various specialties: 3 in radiology, 1 in otolaryngology, 3 in dermatology, and 13 in ophthalmology.
  • All studies assessed clinical outcomes, demonstrating effectiveness and feasibility of DL integration into clinical workflows.
  • Adoption and appropriateness were the most frequently evaluated implementation outcomes.
  • Only one study evaluated implementation costs, and none assessed sustainability.
  • Stakeholder acceptability was evaluated in only 8 studies, indicating a need for broader assessment.
Interpretation:

The review highlights a significant gap in real-world DL implementation research, emphasizing the urgent need for further studies using hybrid effectiveness-implementation designs to enhance clinical adoption.

Limitations:
  • Limited number of studies evaluated implementation costs and sustainability, and there was insufficient assessment of stakeholder acceptability across studies.
Conclusion:

Continued research is essential to facilitate the effective adoption of DL systems in clinical practice, specifically addressing the identified gaps in current studies.

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